I have spent hours looking for a solution through fixing the Nautilus file access bug, but I ended up devising a workaround. If, for example, I want to run Neverwinter Nights II in the ~/games/nwn2/ directory, I simply copy the required DLLs into the directory and set the WINEPREFIX environment variable for that particular Wine session: Code: WINEPREFIX=~/games/nwn2/ wine nwn2.exe Of course, don't forget adding DLL overrides with the correct environment variable: Code: WINEPREFIX=~/games/nwn2/ winecfg Problem solved. :) I hope this is of use to anyone.