If i put manually this file to system32 i've got a new error : wine WINWORD.EXE fixme:actctx:parse_depend_manifests Could not find dependent assembly L"Microsoft.VC80.CRT" err:module:attach_process_dlls "MSVCR80.dll" failed to initialize, aborting err:module:LdrInitializeThunk Main exe initialization for L"C:\\Program Files\\Microsoft Office\\Office12\\WINWORD.EXE" failed, status c0000142 :(