Hello, Is there any reason to install the SetPoint software ? Now, Linux is able to detect your hardware very well. For example, my MX Revolution's buttons are usable in WoW directly without any configuration. I'm using Fedora, with very recent versions of all Linux software. So with other distributions, it may be less detect. I think you should think about BTNX that is very funny for Logitech mice : http://doc.ubuntu-fr.org/btnx But running Wine all the time just for SetPoint is not good, to my mind.