vitamin: Where is the documentation of this? What, specifically, are the filesystem limitations in Wubi that make Wine not function properly, and how can you observe them in a real app? This should be on the download page and in the FAQ. The only specific filesystem-related issue I know of is that Steam does not run from ntfs, and 8.10 should have a new enough kernel that it shouldn't matter (according to the note on the appdb page, and assuming the same issue affects Wubi somehow).
