Thanks for your quick reply. Ok, so how do I know if I run it as root? I am not very familiar with the layout in Ubuntu yet. The way I installed WINE was through System > Administration > Synaptic Package Manager And the rest was automatic. When I view Applications > Wine I see it says a C: Drive. I assume it simulates the C: structure in it's own file then. So if it's not root, it won't interact with programs outside of WINE? But even if it isn't root, if I assume that if WINE recreates the Windows Registry and installs in the same way, then any program that SecuROM might interfere with in Windows might also interfere with the same other programs running under WINE? As far as being safe goes, what it a prefix, and how do I set that up? I want to make sure that if I run any potentially dangerous program it won't interfere with any other program I may want WINE to run. On a similar topic to ask, I wonder. Would WINE enable a Malicious program, such as a Virus, written for Windows, affect Ubuntu? And if so, what would keep it from affect the file structure outside of the WINE C: Drive?