I found alone how to do it : 1-Make a fresh install of your ORIGINAL game The Witcher with wine. 2-Download all needed files from The Witcher Website, this mean : "TWEE_Upgrade.exe" (a ~900mb patch file) "TWEE_YOUR-LANGUAGE_language_pack.exe" "TWEE_adventure_Side_Effects.exe" (optional bonus quest) "TWEE_adventure_The_Price_of_Neutrality.exe" (optional bonus quest) 3-Find yourself witcher.v1.4.5.1282.nodvd.rar and replace the exe of the game with the one in this archive. 4-Now double click on "TWEE_Upgrade.exe" and install the update. You'll notice that it bypassed the registration message. 5-Replace the game exe with a working NO-DVD to bypass the protection requirement (remenber it curently DO NOT WORK with wine, see bug report on the game page) 6-Enjoy the Enhanced Edition of the witcher. Let's hope Wine dev will soon find a way to make the game protection working so there wil be no need of those crap No-DVD files anymore...