jg1 wrote: > However it would be very useful if I could install and execute Wine entirely on a detachable (encrypted) hard drive so that it does not (and preferably cannot) write to another disk? > Is this possible? If so, how? Pls remember I'm a numpty when it comes to cmd line working! No it's not possible. Wine have to write at least registry to the disk. So you can't run it 100% from read-only media. You need at least some memdisk. You can only limit Wine to what "disks" it allows applications to access (disk mapping in winecfg). But you can't set them "read-only" within Wine. However Wine can browse the entire file system (starting from the root (/) ). Also see FAQ (http://wiki.winehq.org/FAQ#head-497f1a295d53dd3444f211df2b13312c7767afa2) about running applications installed under windows.