I have changed /etc/fstab to explicitly mount the NTFS file system. This corrects a number of other problems I have had on Ubuntu HH but I still cannot open the file on the NTFS partition from my program running under Wine. The line I added to /etc/fstab is: # /dev/sda1 UUID=5EA41B7AA41B543D /media/disk-1 ntfs-3g relatime,errors=remount-ro 0 1 This is identical to the mount for the main file system except for the UUID, mount point, and type.