Well, even if you are compiling a 32 bit copy, it won't work on a 64-bit machine. If you fail to meet all the dependancies that Wine requires in order to compile them, when you run ./configure, it will tell you at the end if you are missing any necessary devel files. A successful compilation of Wine will run like any pre-packaged copy made by the Wine developers, except it will run a bit faster on the machine it was compiled on than the pre-packaged ones. If you plan to compile and give the program to others though, they won't reap the same performance benefits. Unless you plan to build a patched copy of Wine for others, I can't see why you'd want to anyway.
