I'm running 1.1.1 on Mac OS X 10.5.4. I have searched about this issue and found nothing and people are running .net apps fine so I think this is a particular problem with Darwine (osx build) .NET installs fine via winetricks and then I can run simple .net apps like QuickGUIDGen, but having a look to the NGen log I noticed there were no assemblies installed (It's supposed to install mscorlib and so after the install. I tried to install manually: Code: wine ngen.exe install "mscorlib, Version=2.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089" /NoDependencies and installs fine, Code: Microsoft (R) CLR Native Image Generator - Version 2.0.50727.42 Copyright (C) Microsoft Corporation 1998-2002. All rights reserved. Installing assembly mscorlib, Version=2.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089 but later, when I do Code: wine ngen executequeueditems I got Code: Exception from HRESULT: 0x80070057 (E_INVALIDARG) This happens with win2k, with winxp you get E_Accessdenied everywhere I have checked the keys corresponding to the CLR service in the Registry as well as .net ones and everything seems ok. I would try with winxp if someone tells me how to pass over access_denied and so (I know sudo doesn't work) I need this for Autocad 2008 (.net 1.1 is fully working on the other hand, we have autocad 2005 working like a charm). A single command "layer" depends on it, but it's a very important one.