I tried 3 wine packages: The macports package This one: http://www.kronenberg.org/darwine/ And this one: http://thisismyinter.net/?p=47 Only the last one can print something. With macports and kronenberg packages I didn't had anything about printers in my win.ini file. With thisismyinter package I have that: [devices] CUPS_PDF=WINEPS.DRV,LPR:CUPS_PDF hp_LaserJet_4345_mfp__8E4A7C_=WINEPS.DRV,LPR:hp_LaserJet_4345_mfp__8E4A7C_ [PrinterPorts] CUPS_PDF=WINEPS.DRV,LPR:CUPS_PDF,15,45 hp_LaserJet_4345_mfp__8E4A7C_=WINEPS.DRV,LPR:hp_LaserJet_4345_mfp__8E4A7C_,15,45 [windows] device=hp_LaserJet_4345_mfp__8E4A7C_,WINEPS.DRV,LPR:hp_LaserJet_4345_mfp__8E4A7C_ I also installed the last xquartz (http://xquartz.macosforge.org/trac/wiki) but I don't think it was needed. I've read that wine needs an additional library to print through cups printers (cups and cups-devel or libwine-print or libwine-cups) (=> http://source.winehq.org/source/documentation/README.fr?v=wine-0.9.24). Maybe that the thisismyinter package include one of them and the other ones not.