Start from a clean wineprefix. Code: rm -rf ~/.wine This will delete your old ~/.wine directory. Install the program. A new ~/.wine directory should be created automatically when you run the setup program. Install vcrun2005 following the directions I gave you earlier. To run the program, first cd to the directory where the executable is located. If you installed to the default location, it should be something like Code: cd '.wine/drive_c/Program Files/Pixologic/ZBrush3' If you installed to a different location, cd to that directory. Then run the program.