What are your DLL overwrites? You can check them by running `winecfg` on the Libraries tab. Such errors could be because of running some Windows libraries that makes low-level NTDLL calls that are not supported by Wine. The other possibility it is the program that uses NTDLL directly to create an LPC connection. LPCs are not implemented and AFAIK are not planned in the near future. In that case you could try to open a bug on http://bugs.winehq.org. Maybe one day the LPC will be implemented to speed up the RPC and a bug report will be a further motivation to do it.
