Well, that mscoree patch is not the patch that i meant; it's only to be able to test autocad without using native dotnet20. The patch i was talking about is http://bugs.winehq.org/attachment.cgi?id=13812 (Sorry there's even lots if unneeded commented crap in it) If it would solve your bug i really wouldn't know; the only thing i know is that AutoCad needs a real installation in wine; it depends on a zillion registry keys that it creates during install. So to summarize: rm -rf ~/.wine and then try again installing (with the hack above) and try running