Thanks for your response. I've always only had one Screen, Monitor and Device specified in the xorg.conf file. The fglrx driver I use takes the DesktopSetup option to tell it to split a single screen over two monitors. As far as the fresh wine prefix, do you mean deleting my ~/.wine directory and reinstalling? I haven't tried it, but it doesn't seem like it should come to that. It wouldn't be a good solution for me anyhow since I'd have to reinstall/configure lots of stuff. But I mean, where is that information stored? How does it remember the location of windows or decide where to put them on startup?