Francesco Pietra wrote: > francesco@deb32:~$ wine "c:\ACDFREE5\CHEMSK.EXE" > Invoking /usr/lib/wine/wine.bin c:\ACDFREE5\CHEMSK.EXE ... You have ancient version on Wine. Upgrade - http://winehq.org/site/download-deb Second - you are not correctly starting application - read FAQ (first question) - http://wiki.winehq.org/FAQ The part about what the current directory should be.