I suppose you could change the fonts in the menus, tooltips and message boxes using winecfg. Go to the "Desktop Integration" tab. There you can set these fonts and font sizes. I do that frequently to get decent-looking apps. Other fonts of the GUI may be "hardwired" into the applications and hard to access. There is, BTW also a "Screen Resolution" slider on the "Graphics" tab. I'm not sure what it does or if it has an effect on the fonts. Just providing a lead here. Good luck. --hasi