Since gentoo does not have 32-bit HAL you have to run winecfg, add cd-rom mapping on "Drives" page, make sure it's type is set to cd-rom. Verify that you do have access to the device (not just the mount point). Then run your program with: Code: cd /mnt/cdrom/ wine "D:\setup.exe" Assuming that you mapped cd-rom to D: drive. And that this is a single-cd install.
