This what is inside the shortcut (.desktop) to my personel app : Exec=env WINEPREFIX="/home/user1/.wine" wine C:\\\\windows\\\\command\\\\start.exe /Unix /home/user1/.wine/dosdevices/w:/exe/myapp.exe (w: having been defined into the Wine config). But anyway, as I already stated, I can launch the exe directly from its directory in a terminal (this is best because there I can read the error message).