On the FAQ I read this : (may be it's not up to date ?) > 2.4. Does Wine run on 64-bit? > > Yes. Normally, installation should be the same as with 32-bit: simply install the Wine package for your distribution. Check the Downloads page. If you need to build Wine from source, see WineOn64bit. > > Note that Wine for 64-bit actually runs in 32-bit mode. This is necessary, as virtually all Windows applications are 32-bit. Support for 64-bit Windows applications is currently experimental (see Wine64). > > Wine is currently offered in 32-bit. 16-bit and 32-bit Windows applications work with it. It runs on both 32-bit and 64-bit Linux/Unix installations. > Wine is also experimentally offered in 64-bit. 32-bit and 64-bit Windows applications (should) work with it. It runs only on 64-bit Linux installations