This is what I did, from the AppDB instructions. Go to etc/mono/2.0 and copy the machine.config file. paste it in wine/drive_c/windows/microsoft.NET/Framework/v2.0.50727/CONFIG I had to create a CONFIG folder, and in fact pasted the machine.config file in the v2.05.0727 folder, and into the CONFIG folder I created. After that, I was able to use Wine to install Office 2010 Pro just fine. Keep in mind, not all the Office applications run under wine.
