This an example of a typical working shortcut in Ubuntu (although I think this is a freedesktop standard) (maybe you have been missing the Path?) [Desktop Entry] Version=1.0 Encoding=UTF-8 Name=Sid Meier's Civilization 4 Exec=env WINEPREFIX="/home/username/WinePrefixes/Civ4" wine "E:\\Civ4\\Civilization4.exe" Type=Application StartupNotify=true Path=/home/username/WinePrefixes/Civ4/dosdevices/e:/Civ4 Icon=/home/username/.local/share/icons/be09_civilization4.0.png GenericName[en_US]= Comment[en_US]=