This has been an ongoing issue with all of the 1.4 releases. In several games, notably Oblivion, Fallout 3, Fallout:NV, and Far Cry, the mouse will not function properly. On main menus, the mouse will be stuck in one quadrant of the screen, as if what the mouse thinks the screen boundaries are is not aligned with the actual boundaries. In game, the mouse swings wildly all over the screen, making actual gameplay impossible. I'm running this with the latest Wineskin, Mac OS 10.7.