I don't remember the mouse working for Mass Effect "out of the box" ever. There's a bunch of "known issues" on Mass Effect and a bunch of suggestions for resolving them in the appdb: http://appdb.winehq.org/objectManager.php?sClass=application&iId=7465 The problem may not be 1.4rc-1, but the clean WINEPREFIX. You might need to install some native DirectX DDLs or something. I vaguely recall there was some mouse-patch for Mass Effect as well, but maybe I'm thinking Mass Effect 2.
