update SUBSCRIPTIONTABLE set ACTIVEFLAG='Y' where mobile_num in (select mobile_num from LOADED_MOBILE_NUMBERS)
Change to:update SUBSCRIPTIONTABLE set ACTIVEFLAG='Y' where exists (select 1 from LOADED_MOBILE_NUMBERS lmn where lmn.mobile_num=SUBSCRIPTIONTABLE.mobile_num);
That should run a lot faster. Make sure you have indexes on both mobile_num columns. Chris