U.S. Department of Health and Human Services
NATIONAL INSTITUTES OF HEALTH NIH News
National Institute of Allergy and Infectious Diseases (NIAID) <https://www.niaid.nih.gov/>
For Immediate Release: Wednesday, March 27, 2019
CONTACT: Ken Pekoc, 301-402-1663, <e-mail:kpekoc@xxxxxxxxxxxxx>
MEDIA AVAILABILITY
RETINAL PRION DISEASE STUDY REDEFINES ROLE FOR BRAIN CELLS
Microglia may benefit, not damage, photoreceptors
WHAT:
National Institutes of Health scientists studying the progression of inherited and infectious eye diseases that can cause blindness have found that microglia, a type of nervous system cell suspected to cause retinal damage, surprisingly had no damaging role during prion disease in mice. In contrast, the study findings indicated that microglia might delay disease progression.
The discovery could apply to studies of inherited photoreceptor degeneration diseases in people, known as retinitis pigmentosa. In retinitis pigmentosa cases, scientists find an influx of microglia near the photoreceptors, which led to the belief that microglia contribute to retina damage.
These inherited diseases appear to damage the retina similarly to prion diseases. Prion diseases are slow degenerative diseases of the central nervous system that occur in people and various other mammals. No vaccines or treatments are available, and the diseases are almost always fatal. Prion diseases primarily involve the brain but also can affect the retina and other tissues.
Expanding on work published in 2018, scientists at NIH's National Institute of Allergy and Infectious Diseases (NIAID) used an experimental drug to eliminate microglia in prion-infected mice. They studied prion disease progression in the retina to see if they could discover additional details that might be obscured in the more complex structure of the brain.
When the scientists examined their prion-infected study mice, they found that photoreceptor damage still occurred -- even somewhat faster -- despite the absence of microglia. They also observed early signs of new prion disease in the photoreceptor cells, which may provide clues as to how prions damage photoreceptors. Their work appears in Acta Neuropathologica Communications.
The NIAID scientists, located at Rocky Mountain Laboratories in Hamilton, Mont., plan to continue to study the toxic interactions between prions and photoreceptor cells to identify ways to block these damaging effects. They also plan to continue studying the role of microglia in deterring the initiation of prion disease.
ARTICLE:
J Striebel et al. Microglia are not required for prion-induced retinal photoreceptor degeneration. Acta Neuropathologica Communications DOI: 10.1186/s40478-019-0702-x <https://doi.org/10.1186/s40478-019-0702-x> (2019).
RELATED:
J Carroll et al. Microglia are critical in host defense against prion disease. Journal of Virology DOI: 10.1128/JVI.00549-18 (2018).
WHO:
Bruce Chesebro, M.D., chief of the NIAID Laboratory of Persistent Viral Diseases, is available to comment on this study.
CONTACT:
To schedule interviews, please contact Ken Pekoc, (301) 402-1663, kpekoc@xxxxxxxxxxxxx.
This press release describes a basic research finding. Basic research increases our understanding of human behavior and biology, which is foundational to advancing new and better ways to prevent, diagnose, and treat disease. Science is an unpredictable and incremental process -- each research advance builds on past discoveries, often in unexpected ways. Most clinical advances would not be possible without the knowledge of fundamental basic research.
NIAID conducts and supports research -- at NIH, throughout the United States, and worldwide -- to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID website <http://www.niaid.nih.gov/>.
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