DESIGNER COMPOUND MAY UNTANGLE DAMAGE LEADING TO SOME DEMENTIAS

[Date Prev][Date Next][Thread Prev][Thread Next][Date Index][Thread Index]

 




U.S. Department of Health and Human Services
NATIONAL INSTITUTES OF HEALTH NIH News
National Institute of Neurological Disorders and Stroke (NINDS) <https://www.ninds.nih.gov/>
For Immediate Release: Wednesday, February 8, 2017

CONTACT: Christopher G. Thomas, 301-496-5751, <e-mail:nindspressteam@xxxxxxxxxxxxx>

DESIGNER COMPOUND MAY UNTANGLE DAMAGE LEADING TO SOME DEMENTIAS
NIH-funded preclinical study suggests a possible treatment for Alzheimer's disease and other neurodegenerative disorders

In a study of mice and monkeys, National Institutes of Health funded researchers showed that they could prevent and reverse some of the brain injury caused by the toxic form of a protein called tau. The results, published in Science Translational Medicine, suggest that the study of compounds, called tau antisense oligonucleotides, that are genetically engineered to block a cell's assembly line production of tau, might be pursued as an effective treatment for a variety of disorders.

Cells throughout the body normally manufacture tau proteins. In several disorders, toxic forms of tau clump together inside dying brain cells and form neurofibrillary tangles, including Alzheimer's disease, tau-associated frontotemporal dementia, chronic traumatic encephalopathy and progressive supranuclear palsy. Currently there are no effective treatments for combating toxic tau.

"This compound may literally help untangle the brain damage caused by tau," said Timothy Miller, M.D., Ph.D., the David Clayson Professor of Neurology at Washington University, St. Louis, and the study's senior author.

Antisense oligonucleotides are short sequences of DNA or RNA programmed to turn genes on or off. Led by Sarah L. DeVos, a graduate student in Dr. Miller's lab, the researchers tested sequences designed to turn tau genes off in mice that are genetically engineered to produce abnormally high levels of a mutant form of the human protein. Tau clusters begin to appear in the brains of 6-month-old mice and accumulate with age. The mice develop neurologic problems and die earlier than control mice.

Injections of the compound into the fluid filled spaces of the mice brains prevented tau clustering in 6-9 month old mice and appeared to reverse clustering in older mice. The compound also caused older mice to live longer and have healthier brains than mice that received a placebo. In addition, the compound prevented the older mice from losing their ability to build nests.

"These results open a promising new door," said Margaret Sutherland, Ph.D., program director at NIH's National Institute of Neurological Disorders and Stroke (NINDS). "They suggest that antisense oligonucleotides may be effective tools for tackling tau-associated disorders."

Currently researchers are conducting early phase clinical trials on the safety and effectiveness of antisense oligonucleotides designed to treat several neurological disorders, including Huntington's disease and amyotrophic lateral sclerosis. The U.S. Food and Drug Administration recently approved the use of an antisense oligonucleotide for the treatment of spinal muscular atrophy, a hereditary disorder that weakens the muscles of infants and children.

Further experiments on non-human primates suggested that the antisense oligonucleotides tested in mice could reach important areas of larger brains and turn off tau. In comparison with placebo, two spinal tap injections of the compound appeared to reduce tau protein levels in the brains and spinal cords of Cynomologus monkeys. As the researchers saw with the mice, injections of the compound caused almost no side effects.

Nevertheless, the researchers concluded that the compound needs to be fully tested for safety before it can be tried in humans. They are taking the next steps towards translating it into a possible treatment for a variety of tau related disorders.

This study was supported by grants from NINDS (NS078398, NS074194, NS057105) and National Institute on Aging (AG05681, AG044719), the Tau Consortium and Cure PSP. Ionis Pharmaceuticals supplied the authors with all of the antisense oligonucleotides in the described work.

About NINDS <http://www.ninds.nih.gov> is the nation's leading funder of research on the brain and nervous system. The mission of NINDS is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease.

About the National Institute on Aging: The NIA leads the federal government effort conducting and supporting research on aging and the health and well-being of older people. It provides information on age-related cognitive change and neurodegenerative disease specifically at its Alzheimer's Disease Education and Referral (ADEAR) Center at <www.nia.nih.gov/alzheimers>.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit <www.nih.gov>.

NIH...Turning Discovery into Health -- Registered, U.S. Patent and Trademark Office
---
ARTICLE: DeVos et al. Tau Reduction Prevents Neuronal Loss and Reverses Pathological Tau Deposition and Seeding in Mice with Tauopathy. Science Translational Medicine, January 25, 2017 DOI: 10.1126/scitranslmed.aah7029
---
The online version of this news release contains an image of a mouse brain scan. <https://www.nih.gov/2017/20170208-anti-sense-tau.jpg>
CAPTION: Untangling Dementia - Scientists used a designer compound to prevent and reverse brain damage caused by tau in mice. Courtesy of Miller lab, Washington University, St. Louis

###

This NIH News Release is available online at:
<https://www.nih.gov/news-events/news-releases/designer-compound-may-untangle-damage-leading-some-dementias>.

To subscribe (or unsubscribe) from NIH News Release mailings, go to
<http://service.govdelivery.com/service/subscribe.html?code=USNIH_1>.
If you subscribed via the NIH LISTSERV, go to <https://list.nih.gov/cgi-bin/wa.exe?A0=nihpress>.




[Index of Archives]     [CDC News]     [FDA News]     [USDA News]     [Yosemite News]     [Steve's Art]     [PhotoForum]     [SB Lupus]     [STB]

  Powered by Linux