U.S. Department of Health and Human Services NATIONAL INSTITUTES OF HEALTH NIH News National Institute of Allergy and Infectious Diseases (NIAID) http://www3.niaid.nih.gov/ FOR IMMEDIATE RELEASE: Friday, November 25, 2005 CONTACT: Kathy Stover, 301-402-1663, kstover@xxxxxxxxxxxxx AGRICULTURAL WORKERS AT INCREASED RISK FOR INFECTION WITH ANIMAL FLU VIRUSES Findings May Have Implications for Pandemic Flu Planning Farmers, veterinarians and meat processors who routinely come into contact with pigs in their jobs have a markedly increased risk of infection with flu viruses that infect pigs, according to a study funded in part by the National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health (NIH). While the findings are not entirely unexpected, the strikingly higher risk of infection coupled with the fact that pigs can be infected by swine viruses, bird (avian) viruses as well as human flu viruses -- thereby acting as a virtual virus "mixing bowl," especially on farms where pigs, chickens and people coexist -- is a potential public health concern, the study authors assert. The paper appears online this week in "Clinical Infectious Diseases". "Pigs play a role in transmitting influenza virus to humans," says NIAID Director Anthony S. Fauci, M.D. "The worry is that if a pig were to become simultaneously infected with both a human and an avian influenza virus, genes from these viruses could reassemble into a new virus that could be transmitted to and cause disease in people." The study results strongly suggest that occupational exposure to pigs significantly increases the risk of developing swine influenza infection. Agricultural workers should, therefore, be considered in developing flu pandemic surveillance plans and antiviral and immunization strategies, according to the study's co-investigator, Gregory C. Gray, M.D., director of the University of Iowa Center for Emerging Infectious Diseases. "If migratory birds introduce the H5N1 bird flu virus into swine or poultry populations in this country, agricultural workers may be at a much greater risk of developing a variant H5N1 and passing it along to non-agricultural workers," Gray says. "Not protecting agricultural workers could amplify influenza transmission among humans and domestic animals during a pandemic and cause considerable damage to the swine and poultry industries, as well as the U.S. economy." While swine in other countries have been infected by the H5N1 virus, to date, the virus has not become readily transmissible between swine. Swine influenza infections generally produce mild or no symptoms in both pigs and humans. However, exposure to swine flu virus at a 1988 Wisconsin county fair resulted in serious illness for 50 swine exhibitors and three of their family members; one previously healthy woman who became infected died. The U.S. swine industry, which employs about 575,000 people, has shifted during the past 60 years from primarily small herds located on family farms to large herds maintained in expansive but confined agricultural facilities. Crowded conditions coupled with the constant introduction of young pigs to existing herds have made swine flu infections among pigs a year-round occurrence rather than the seasonal event they once were. As a result, there is a constant opportunity for people who are occupationally exposed to pigs to become infected with influenza viruses and, conversely, a continual opportunity for human flu viruses to mix with swine or bird flu viruses. To determine the prevalence of swine influenza infection among swine-exposed employees, the researchers, led by Dr. Gray and graduate student Kendall P. Myers, examined serum samples taken from four adult populations in Iowa between 2002 and 2004. Three populations were occupational groups exposed to pigs: 111 farmers, 97 meat processing workers and 65 veterinarians. The fourth control group included 79 volunteers from the University of Iowa with no occupational pig exposure. The researchers tested the serum samples for antibodies to several then-current swine and human influenza A viruses. The results showed that all three occupational study groups had markedly elevated antibodies to swine flu viruses compared with the control group. Farmers had the strongest indication of exposure to swine flu viruses, as much as 35 times higher than the control group. Similarly, comparable values were as much as 18 times higher for veterinarians and as much as 7 times higher for meat processors than the control group. In contrast, exposure to human flu virus in the occupational groups was not significantly different than that of the control group. To date, the H5N1 avian virus has not appeared in the United States in any animal population or in humans. NIAID is a component of the National Institutes of Health, an agency of the U.S. Department of Health and Human Services. NIAID supports basic and applied research to prevent, diagnose and treat infectious diseases such as HIV/AIDS and other sexually transmitted infections, influenza, tuberculosis, malaria and illness from potential agents of bioterrorism. NIAID also supports research on transplantation and immune-related illnesses, including autoimmune disorders, asthma and allergies. ------------------------------------------------ References: KP Myers et al. Are swine workers in the United States at increased risk of infection with zoonotic influenza virus? "Clinical Infectious Diseases". Published online November 22, 2005. Appearing in the January 1, 2006 print edition. News releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at http://www.niaid.nih.gov. The National Institutes of Health (NIH) -- "The Nation's Medical Research Agency" -- includes 27 Institutes and Centers and is a component of the U. S. Department of Health and Human Services. It is the primary Federal agency for conducting and supporting basic, clinical, and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov. ## This NIH News Release is available online at: http://www.nih.gov/news/pr/nov2005/niaid-25.htm. 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