hello. Here are some notes on how to configure the Dectalk PC, taken from work I did on this product many years ago. 1. The I/O base addresses choices for the Dectalk are: 0x240, 0x250, 0x340 or 0x350 2. the BIOS base choices are: 0xc000, 0xc800, 0xd000 or 0xd800 3. Although the Dectalk is capable of running with interrupts enabled, my notes indicate the Dectalk software runs the synthesizer in polling mode, so a discussion of which interrupt to use is mostly academic. 4. It appears the default i/o address setting for the Dectalk PC is 0x240. My suggestion is to edit your config.bat file with each of the choices listed above, in the order listed, and try and start up the Dectalk software. You won't hurt anything with this technique, though you may need to reboot several times as my notes say that you can hang the machine by trying to get the software to talk to the hardware at the wrong address. To prevent yourself from getting locked out of the system, don't set the dectalk to come up talking automatically on boot until you've confirmed that you have the right settings and that it works when started manually. By doing things this way, you shouldn't have to adjust the jumpers on the card at all. I hope these notes are helpful. It has been a long time since I touched this card, 25 years if the dates on my notes are to be believed, so I may be leaving some details out. -Brian