I have the same am335x-based system running with both 3.18.x and 5.4.x (6.2.1 too) kernels. In the full setup the system handles 4x FT4232-H chips. # lsusb -t /: Bus 02.Port 1: Dev 1, Class=root_hub, Driver=musb-hdrc/1p, 480M |__ Port 1: Dev 2, If 0, Class=, Driver=hub/4p, 480M |__ Port 2: Dev 3, If 0, Class=, Driver=ftdi_sio, 480M |__ Port 2: Dev 3, If 1, Class=, Driver=ftdi_sio, 480M |__ Port 2: Dev 3, If 2, Class=, Driver=ftdi_sio, 480M |__ Port 2: Dev 3, If 3, Class=, Driver=ftdi_sio, 480M |__ Port 3: Dev 4, If 1, Class=, Driver=ftdi_sio, 480M |__ Port 3: Dev 4, If 2, Class=, Driver=ftdi_sio, 480M |__ Port 3: Dev 4, If 0, Class=, Driver=ftdi_sio, 480M |__ Port 3: Dev 4, If 3, Class=, Driver=ftdi_sio, 480M /: Bus 01.Port 1: Dev 1, Class=root_hub, Driver=musb-hdrc/1p, 480M |__ Port 1: Dev 2, If 0, Class=, Driver=hub/4p, 480M |__ Port 2: Dev 3, If 0, Class=, Driver=ftdi_sio, 480M |__ Port 2: Dev 3, If 3, Class=, Driver=ftdi_sio, 480M |__ Port 2: Dev 3, If 1, Class=, Driver=ftdi_sio, 480M |__ Port 2: Dev 3, If 2, Class=, Driver=ftdi_sio, 480M |__ Port 3: Dev 4, If 0, Class=, Driver=ftdi_sio, 480M |__ Port 3: Dev 4, If 1, Class=, Driver=ftdi_sio, 480M |__ Port 3: Dev 4, If 2, Class=, Driver=ftdi_sio, 480M |__ Port 3: Dev 4, If 3, Class=, Driver=ftdi_sio, 480M When I open all 16 serial ports with the LOW_LATENCY flag in the latest kernels, the system performance drops dramatically. It is best to watch via iperf3: Kernel 6.2.1 16 serial ports closed: 90.2 Mbits/sec 16 serial ports opened without LOW_LATENCY: 88.3 Mbits/sec 16 serial ports opened with LOW_LATENCY: 12.1 Mbits/sec Kernel: 3.18.1 16 serial ports closed: 61.1 Mbits/sec 16 serial ports opened without LOW_LATENCY: 53.7 Mbits/sec 16 serial ports opened with LOW_LATENCY: 37.2 Mbits/sec Any idea why the performance drop is so big? Regards, Yegor