Brad mentioned VST Plugins in an earlier post. I've had no luck at all with any of the Linux methods. I have had perfect success with a "free" version of Muzsys that Computer Music Magazine had on one of their CD's: CompMuzsys. This works flawlessly under WINE. It is an "entry level" piece of software, but does have fairly good mixing. It has lots of latency and only primitive MIDI editing. But if I'm in Linux and want to do something quickly without rebooting, this is the way I go. CompMuzsys is the only Windows audio program that I have seen that works under Linux just like it does under Windows. I have dozens of VST and VSTi Plugins, and every single one of them works. This shows that IT IS POSSIBLE. I find it amusing that to run VST or VSTi plugins, I had to install a piece of Windows software. It makes me wonder if the future of music production using GNU/Linux is to run (entry level) Windows audio software under WINE.