IIR, Multics from several years earlier. I'd have to dig through old manuals to remember what CTSS did, but that system (and the IBM Model 1050 and 2741 devices often used as terminals with it) were somewhat pre-ASCII (and long before ECMA-48/ ANSI X3.64 and the VT100 and friends) and, IIR, sent and received shift and rotate codes rather than what we would normally consider character codes today. The character codes were just input to device drivers that dealt with device characteristics
Multics was based on EBCDIC which had a New Line (NL) character but no CR or LF. The ARPANET went with the ASCII standard. But I never forgave the ANSI committee for taking left arrow out of the character set (as a replacement operator).
Then there was the day that BBN loaded ASCII to EBCDIC tables into the TIPs that would not generate the line delete or character delete characters for Multics. They said it was an accident. ;-)
Take care, John