Thanks to everyone who have responded. I'm going to go with GNU GMP (BigNum) library for now but it's taking too much memory. I actually am dealing with 2D matrices of very large numbers. These matrices are a result of a dynamic programming algorithm applied to large genomic DNA sequences. So 80 bit arithmetic becomes a limiting factor when I start going beyond 15K nucleotides. Usman On Sat, 14 Oct 2006, John (Eljay) Love-Jensen wrote: > Hi Usman, > > The conversation is somewhat off topic for this forum. But interesting! > > As an alternative (since you asked for alternatives), and in the vein of "using the right tool for the job", I would urge you to consider using Mathematica as your processing engine of your large data sets. > > Sincerely, > --Eljay >