Note that there are already Live DVDs and at least one (Games Spin) that is limited by the 4 GiB iso size so as to be downloadable on FAT systems.
Many people who have a choice prefer USB2.0 flash memory storage over DVD because it has much lower latency (seeks are much faster) and does not degrade the drive [wear] nor the platter [scratches] during frequent or intensive use. The downside is lower capacity in readily-available units ("4GB" [or even "2GB"] instead of "4.7GB"), higher initial cost for media (typical in US: 4GB flash $9; DVD+R $0.40), different physical attachment, different BIOS capability.
There is also a good chance that Squashfs will support lzma compression by F13, which should be a noticeable help to spins up against their iso size limits.
Squashfs and lzma have been living together happily for years: http://www.squashfs-lzma.org/ Are you sure that squashfs in Fedora Project is not using lzma? -- -- fedora-devel-list mailing list fedora-devel-list@xxxxxxxxxx https://www.redhat.com/mailman/listinfo/fedora-devel-list