ClamAV is probably your best bet.
That said, the question is, what do you scan? It can be used several
ways, typically scanning files on demand... its not an intrusion
detection system like most MS Windows scanners, where it automatically
scans every file being read or written (while slowing the system down
300%). If your system isn't handling 'files', it becomes harder to
figure out what to do with it... I suppose you could crontab a nightly
scan of all files on the system with clamscan, or something. of course,
you want to run freshclam once or twice a day to pick up new definitions.
I most typically use ClamAV in my email flow, where MailScanner runs
every inbound (and outbound) email through it. I've also run it
periodically against file systems used as a file server.
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