sendmail - No longer the security nightmare it used to be, but it is the slower of the bunch.
are we talking about sendmail X? ;)
postfix - The easiest to configure. Has enough features and speed to keep most people happy.
hmm...i don't know...qmail appears to me to be the easiest of them all due to its utter simplicity (and lack of features/necessary behavior)
exim - Fast and powerful. Lots of features and highly configurable. But ONLY if you know very well what you are going. Not as hard as sendmail to configure (think sendmail.cf), but much harder than postfix. Expecially recomended for people (like me) that enjoy micromanaging and customizing every small detail. ACL features are a god given.
I must take a look at exim one of these days.
qmail - (Take with a grain of salt, since I dislike dbj) A pain. It is fast and secure, as long as you use the stock package. But you will need to include several external packages to get even basic functionality, and everything about it (except SMTP protocol itself) is non standard, and the configuration is spread between a lot of files and directories. But it really is fast (slightly faster than exim in some cases, about the same in others).
You could run qmail-smtpd out of xinetd...and run qmail without daemontools and log to syslog. But if you are into djb's stuff you do end up using the rest of his good stuff.
As you can see, I use Exim so, again, take another grain of salt. My current exim setup is, as far as I know, impossible to reproduce with any other MTA, unless you use several external hacks (multiple instances with different configurations, with port redirection, to name just one).
When you say multiple instances, I assume multiple queues too?
But most of the time, when recomending a MTA to others, I say postfix.
:D - qmail not suitable for today's Internet as an MX mta without patching and sendmail a pain to learn/understand if you are not familiar with m4
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