performance and interrupts

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I am playing around with irqbalance to tune my 8 core system so I came
across this page,
http://kb.fusionio.com/KB/a65/irqbalance-avoid-overloading-cpu-0-with-interrupt-requests.aspx

Now, lets say I disable irqbalance which will stop my autobalance and
I pin all of my interrupts to core 0 and pin eth0 and eth1 to core 1.
My application is network and CPU hungry. I am planning to dedicate
cpu 3 to 8 for the application using taskset.  Is there any draw back
to this?
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