Vaccine Code Set Release Notes 7/28/2022

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NCIRD National Center for Immunization and Respiratory Diseases


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Vaccine Code Set Update Publication Date: July 28, 2022

The individual filenames included in this distribution contain the publication date (20220728)


Release Notes: This release includes updates for one code set file only; the CPT to CVX crosswalk.


Release notes are designed as a guide to highlight changes that have been made to the vaccine codes since the last publication. They should not be used as the primary source of code information. The vaccine code files themselves should be utilized.


Vaccine Code Set Updates

This release includes the following vaccine code set updates:

  1. Smallpox/Monkeypox vaccine (JYNNEOS) CPT code added and mapped to CVX code
  2. Smallpox vaccine (ACAM2000) CPT code added and mapped to CVX code

Vaccine Product

CVX Code

CVX Description

CPT Code

CPT Description

JYNNEOS Smallpox-Monkeypox


Vaccinia, smallpox monkeypox vaccine, live attenuated, preservative free


Smallpox and monkeypox vaccine, attenuated vaccinia virus, live, non-replicating, preservative free, 0.5 mL dosage, suspension, for subcutaneous use

ACAM2000 Smallpox


vaccinia (smallpox) vaccine


Vaccinia (smallpox) virus vaccine, live, lyophilized, 0.3 mL dosage, for percutaneous use


Centers for Disease Control and Prevention

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