Title: MMWR Vol. 58 / No. RR-2
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Recommendations and Reports
Volume 58, No. RR-2
February 6, 2009
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Prevention of Rotavirus Gastroenteritis Among Infants and Children
Recommendations of the Advisory Committee
on Immunization Practices (ACIP)
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Rotavirus is the most common cause of severe gastroenteritis in infants and young children worldwide. In February 2006, a live, oral, human-bovine reassortant rotavirus vaccine (RotaTeq® [RV5]) was licensed as a 3-dose series for use among U.S. infants for the prevention of rotavirus gastroenteritis, and the Advisory Committee on Immunization Practices (ACIP) recommended routine use of RV5 among U.S. infants. In April 2008, a live, oral, human attenuated
rotavirus vaccine (Rotarix® [RV1]) was licensed
as a 2-dose series for use among U.S. infants,
and in June 2008, ACIP updated its rotavirus
vaccine recommendations to include use of RV1. This report updates and replaces the 2006
ACIP statement for prevention of rotavirus gastroenteritis. ACIP recommends routine vaccination of U.S. infants with rotavirus vaccine. RV5 and RV1 differ in composition and schedule
of administration. RV5 is to be administered
orally in a 3-dose series, with doses administered
at ages 2, 4, and 6 months. RV1 is to be administered orally in a 2-dose series, with doses administered at ages 2 and 4 months. ACIP does not express a preference for either RV5 or RV1.
The recommendations in this report also address the maximum ages for doses, contraindications, precautions, and special situations for
the administration of rotavirus vaccine.
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Department of Health and Human Services
Centers for Disease Control and Prevention
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