Because no one have mentioned this. I will :)If you plan to use centralized hosting as I presume, you really need to thing about GFS... it is significantly better then AFS & NFS.
About the configurations... most of the daemons(FTP,DNS,MTA) support DB backends. This improves the configurations greatly.
About the logs... on many mass hostings apache is logging on to one log file which is fifo pipe to a Perl or C/C++ program which is sorting the logs... In my experience the C programs where very good to handle big loads.
The administration... I really don't thing that CPanel,Plesk,Webmin or Confixx can handle such a load. You will need to write the admin panel your self. If you use SQL as a backends to your daemons... this will help you do this part easier.
You will have one bigger issue in all this...SECURITY! How will you will configure your apache is the biggest problem.I have configured my Apaches in chrooted envoirment and prepatched the kernels with either RSBAC or SELinux support to handle most of the security problems. But about apache it is a very good idea to have it with patched suexec wrapper that matches your needs.
User issues:All users have to have backup as option. You will need to thing about hourly,daily,weekly & monthly backups. You will need a separate backup/storage system with enough space to handle such a load.
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