To clarify a bit regarding what exactly the regression is:
This works in earlier Apache 2.4 versions:
AddHandler proxy:unix:/run/sockets/uwsgi-fcgi.sock|uwsgi:// .php
But with 2.4.60 and newer, this results in an error message:
AH10097: error parsing URL //: Invalid host/port
If one then tries to add localhost as a "host", as has been a workaround for e.g. Sympa using fcgi, uwsgi gets confused as described in the issue reported in Github.
It appears therefore that Apache 2.4 handles uwsgi:// and uwsgi://localhost differently in how parameters are passed, and that this causes the regression.
-- Jan