Let's say I have libvirt [root@vmhost2 ~]# virsh version Compiled against library: libvirt 4.5.0 Using library: libvirt 4.5.0 Using API: QEMU 4.5.0 Running hypervisor: QEMU 2.12.0 [root@vmhost2 ~]# running on centos 8 and then I have this card [root@vmhost2 ~]# virsh nodedev-dumpxml pci_0000_01_00_0 <device> <name>pci_0000_01_00_0</name> <path>/sys/devices/pci0000:00/0000:00:01.0/0000:01:00.0</path> <parent>pci_0000_00_01_0</parent> <driver> <name>mlx4_core</name> </driver> <capability type='pci'> <domain>0</domain> <bus>1</bus> <slot>0</slot> <function>0</function> <product id='0x1003'>MT27500 Family [ConnectX-3]</product> <vendor id='0x15b3'>Mellanox Technologies</vendor> <iommuGroup number='1'> <address domain='0x0000' bus='0x00' slot='0x01' function='0x0'/> <address domain='0x0000' bus='0x01' slot='0x00' function='0x0'/> </iommuGroup> <pci-express> <link validity='cap' port='8' speed='8' width='8'/> <link validity='sta' speed='5' width='8'/> </pci-express> </capability> </device> which I added to the guest (arch='x86_64' machine='pc-q35-rhel7.6.0') as <hostdev mode='subsystem' type='pci' managed='yes'> <source> <address domain='0x0000' bus='0x01' slot='0x00' function='0x0'/> </source> <address type='pci' domain='0x0000' bus='0x08' slot='0x00' function='0x0'/> </hostdev> When I try to start the guest I get the following error message: [root@vmhost2 ~]# virsh start testfedora error: Failed to start domain testfedora error: internal error: qemu unexpectedly closed the monitor: 2020-04-24T20:01:35.341020Z qemu-kvm: -device vfio-pci,host=01:00.0,id=hostdev0,bus=pci.8,addr=0x0: vfio error: 0000:01:00.0: failed to setup INTx fd: Operation not permitted [root@vmhost2 ~]# Why is it telling me that is not permitted?