I had this issue with qjackctl and was referred here https://github.com/rncbc/qjackctl/issues/96 bash-5.0$ uname -a Linux guixlaptop 5.4.50 #1 SMP 1 x86_64 GNU/Linux bash-5.0$ lspci 00:00.0 Host bridge: Advanced Micro Devices, Inc. [AMD] Raven/Raven2 Root Complex 00:00.2 IOMMU: Advanced Micro Devices, Inc. [AMD] Raven/Raven2 IOMMU 00:01.0 Host bridge: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-1fh) PCIe Dummy Host Bridge 00:01.2 PCI bridge: Advanced Micro Devices, Inc. [AMD] Raven/Raven2 PCIe GPP Bridge [6:0] 00:01.6 PCI bridge: Advanced Micro Devices, Inc. [AMD] Raven/Raven2 PCIe GPP Bridge [6:0] 00:01.7 PCI bridge: Advanced Micro Devices, Inc. [AMD] Raven/Raven2 PCIe GPP Bridge [6:0] 00:08.0 Host bridge: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 00h-1fh) PCIe Dummy Host Bridge 00:08.1 PCI bridge: Advanced Micro Devices, Inc. [AMD] Raven/Raven2 Internal PCIe GPP Bridge 0 to Bus A 00:08.2 PCI bridge: Advanced Micro Devices, Inc. [AMD] Raven/Raven2 Internal PCIe GPP Bridge 0 to Bus B 00:14.0 SMBus: Advanced Micro Devices, Inc. [AMD] FCH SMBus Controller (rev 61) 00:14.3 ISA bridge: Advanced Micro Devices, Inc. [AMD] FCH LPC Bridge (rev 51) 00:18.0 Host bridge: Advanced Micro Devices, Inc. [AMD] Raven/Raven2 Device 24: Function 0 00:18.1 Host bridge: Advanced Micro Devices, Inc. [AMD] Raven/Raven2 Device 24: Function 1 00:18.2 Host bridge: Advanced Micro Devices, Inc. [AMD] Raven/Raven2 Device 24: Function 2 00:18.3 Host bridge: Advanced Micro Devices, Inc. [AMD] Raven/Raven2 Device 24: Function 3 00:18.4 Host bridge: Advanced Micro Devices, Inc. [AMD] Raven/Raven2 Device 24: Function 4 00:18.5 Host bridge: Advanced Micro Devices, Inc. [AMD] Raven/Raven2 Device 24: Function 5 00:18.6 Host bridge: Advanced Micro Devices, Inc. [AMD] Raven/Raven2 Device 24: Function 6 00:18.7 Host bridge: Advanced Micro Devices, Inc. [AMD] Raven/Raven2 Device 24: Function 7 01:00.0 Non-Volatile memory controller: Samsung Electronics Co Ltd NVMe SSD Controller SM981/PM981/PM983 02:00.0 Ethernet controller: Realtek Semiconductor Co., Ltd. RTL8111/8168/8411 PCI Express Gigabit Ethernet Controller (rev 15) 03:00.0 Network controller: Qualcomm Atheros QCA9377 802.11ac Wireless Network Adapter (rev 31) 04:00.0 VGA compatible controller: Advanced Micro Devices, Inc. [AMD/ATI] Raven Ridge [Radeon Vega Series / Radeon Vega Mobile Series] (rev c5) 04:00.1 Audio device: Advanced Micro Devices, Inc. [AMD/ATI] Raven/Raven2/Fenghuang HDMI/DP Audio Controller 04:00.2 Encryption controller: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 10h-1fh) Platform Security Processor 04:00.3 USB controller: Advanced Micro Devices, Inc. [AMD] Raven USB 3.1 04:00.4 USB controller: Advanced Micro Devices, Inc. [AMD] Raven USB 3.1 04:00.6 Audio device: Advanced Micro Devices, Inc. [AMD] Family 17h (Models 10h-1fh) HD Audio Controller 05:00.0 SATA controller: Advanced Micro Devices, Inc. [AMD] FCH SATA Controller [AHCI mode] (rev 61) bash-5.0$ lsusb Bus 003 Device 003: ID 0cf3:e500 Qualcomm Atheros Communications USB2.0 Hub Bus 002 Device 001: ID 1d6b:0003 Linux Foundation 3.0 root hub Bus 004 Device 001: ID 1d6b:0003 Linux Foundation 3.0 root hub Bus 001 Device 002: ID 04f2:b604 Chicony Electronics Co., Ltd Integrated Camera (1280x720@30) Bus 003 Device 002: ID 05e3:0608 Genesys Logic, Inc. Hub Bus 001 Device 001: ID 1d6b:0002 Linux Foundation 2.0 root hub Bus 003 Device 001: ID 1d6b:0002 Linux Foundation 2.0 root hub bash-5.0$ aplay -l **** List of PLAYBACK Hardware Devices **** card 0: Generic [HD-Audio Generic], device 3: HDMI 0 [HDMI 0] Subdevices: 1/1 Subdevice #0: subdevice #0 card 1: Generic_1 [HD-Audio Generic], device 0: CX20751/2 Analog [CX20751/2 Analog] Subdevices: 1/1 Subdevice #0: subdevice #0 bash-5.0$ aplay -v /home/nathan/Downloads/*.wav ALSA lib pcm_dmix.c:1089:(snd_pcm_dmix_open) unable to open slave aplay: main:830: audio open error: No such file or directory Using Guix System _______________________________________________ Alsa-user mailing list Alsa-user@xxxxxxxxxxxxxxxxxxxxx https://lists.sourceforge.net/lists/listinfo/alsa-user